TGF-β Receptor Inhibitors

ALK1

ALK2

ALK3

ALK4

ALK5

ALK6

ALK7

TGFβR2

ACVR2A

ACVR2B

BMP

GDF15

TGF-β Receptor Inhibitors, Agonists, Antagonists, Activators & Degraders

Product Name	ALK1	ALK2	ALK3	ALK4	ALK5	ALK6	ALK7	TGFβR2	ACVR2A	ACVR2B	BMP	GDF15	Purity
SB-431542				ALK4, IC₅₀: 1 μM	ALK5, IC₅₀: 0.75 μM		ALK7, IC₅₀: 2 μM						99.85%
A 83-01				ALK4, IC₅₀: 45 nM	ALK5, IC₅₀: 12 nM		ALK7, IC₅₀: 7.5 nM						99.41%
Dorsomorphin		ACVR1	BMPR1A			ALK6							99.91%
LDN193189		ACVR1, IC₅₀: 5 nM	BMPR1A, IC₅₀: 30 nM										99.72%
THR-123 TFA			BMPR1A
Dorsomorphin dihydrochloride		ACVR1	BMPR1A			ALK6							99.91%
RepSox					ALK5, IC₅₀: 4 nM								99.92%
Bimagrumab									ACVR2A, Kd: 434 pM	ACVR2B, Kd: 1.7 pM			99.31%
Ponsegromab												GDF15	99.60%
Vactosertib					ALK5, IC₅₀: 12.9 nM								99.53%
LDN193189 Tetrahydrochloride		ACVR1, IC₅₀: 5 nM	BMPR1A, IC₅₀: 30 nM										99.79%
A 83-01 sodium				ALK4, IC₅₀: 45 nM	ALK5, IC₅₀: 12 nM		ALK7, IC₅₀: 7.5 nM						98.03%
Sotatercept									ACVR2A				99.94%
N-Acetyltaurine												GDF15	99.91%
SB-431542 (GMP)				ALK4, IC₅₀: 1 μM	ALK5, IC₅₀: 0.75 μM		ALK7, IC₅₀: 2 μM
Visugromab												GDF15	98.40%
LDN-214117	ALK1, IC₅₀: 27 nM	ACVR1, IC₅₀: 24 nM	BMPR1A, IC₅₀: 1171 nM		ALK5, IC₅₀: 3000 nM								99.54%
GLPG3312									ACVR2A, IC₅₀: 860 nM				98.63%
LDN-212854	ALK1, IC₅₀: 2.4 nM	ACVR1, IC₅₀: 1.3 nM	BMPR1A, IC₅₀: 85.8 nM	ALK4, IC₅₀: 2133 nM	ALK5, IC₅₀: 9276 nM								99.62%
ML347	ALK1, IC₅₀: 46 nM	ACVR1, IC₅₀: 32 nM	BMPR1A, IC₅₀: 10800 nM										99.94%
R-268712					TGFBR1, IC₅₀: 2.5 nM								99.92%
Vactosertib Hydrochloride					ALK5, IC₅₀: 12.9 nM								99.22%
Fidrisertib	ALK1, IC₅₀: 3 nM	ALK2 R206H, IC₅₀: 0.2 nM ALK2, IC₅₀: 0.6 nM		ALK4, IC₅₀: 65 nM	ALK5, IC₅₀: 155 nM	ALK6, IC₅₀: 24 nM		TGF-βR2, IC₅₀: 67 nM	ACVR2A, IC₅₀: 9096 nM				98.58%
THRX-144644					ALK5, IC₅₀: 0.14 nM								99.90%
Ontunisertib					ALK5								99.95%
Zilurgisertib		ALK2, IC₅₀: 15 nM											98.25%
IN-1130					ALK5								99.93%
OD36		ACVR1, Kd: 37 nM ACVR1, IC₅₀: 47 nM ALK2 R206H, IC₅₀: 22 nM											99.33%
EW-7195					ALK5, IC₅₀: 4.83 nM								98.84%
A 83-01 (Standard)				ALK4, IC₅₀: 45 nM	ALK5, IC₅₀: 12 nM		ALK7, IC₅₀: 7.5 nM
AZ12601011				ALK4			ALK7						99.78%
ALK2-IN-2		ACVR1, IC₅₀: 9 nM											99.93%
Itacnosertib		ACVR1, IC₅₀: 8 nM											99.06%
AZ12799734	ALK1, Kd: 7.1 μM	ACVR1, Kd: 6.2 μM	BMPR1A, Kd: 40 μM	ALK4, Kd: 1 μM	ALK5, Kd: 0.74 μM TGFBR1, IC₅₀: 47 nM	ALK6, Kd: 0.017 μM							98.67%
Nisevokitug								TGF-βR2
Rilogrotug												GDF15	99.9%
KER047		ALK2											98.80%
Itacnosertib hydrochloride		ACVR1, IC₅₀: 8 nM											99.43%
KER047 succinate		ALK2											98.93%
BI-4659					TGFBR1, IC₅₀: 19 nM								99.78%
M4K-2009		ALK2											99.35%
ALK5-IN-34					ALK5, IC₅₀: <10 nM								98.21%
AMPK activator 12												GDF15	99.68%
CDD-2789	ALK1, Kd: 3.9 nM ALK1, IC₅₀: 10.07 μM	ALK2, Kd: 2.1 nM ACVR1, IC₅₀: 0.54 μM	BMPR1A, Kd: 541 nM		TGFBR1, Kd: 847 nM	ALK6, Kd: 254 nM
TGFβRII-IN-3								TGF-βR2, IC₅₀: 4.1 μM					99.51%
OD36 hydrochloride		ACVR1, Kd: 37 nM ACVR1, IC₅₀: 47 nM ALK2 R206H, IC₅₀: 22 nM
Gdf15 Mouse Pre-designed siRNA Set A												GDF15
GDF15 Human Pre-designed siRNA Set A												GDF15
M4K2281		ALK2, IC₅₀: 2 nM			ALK5, IC₅₀: 350 nM
THR-123			BMPR1A
ALK5-IN-33					ALK5, IC₅₀: ≤10 nM
J-1149					ALK5, IC₅₀: 0.017 μM
YXX0248												GDF15
RKER-216		ACVR1, Kd: 58.7 pM
Visugromab (Powder)												GDF15
ActRIIB-IN-2										ACVR2B, IC₅₀: 1.1 nM
TGFβRII-IN-2								TGF-βR2, IC₅₀: 2.4 μM
ALK5-IN-85					ALK5, IC₅₀: <100 nM
ALK5-IN-25					ALK5, IC₅₀: ≤10 nM
M4K2308		ALK2, IC₅₀: 2 nM			ALK5, IC₅₀: 224 nM
MU1700	ALK1, IC₅₀: 13 nM	ALK2, IC₅₀: 6 nM				ALK6, IC₅₀: 41 nM
ALK5-IN-27					ALK5, IC₅₀: ≤10 nM
HM-279	ALK1, IC₅₀: 21.0 nM	ALK2, IC₅₀: 64.7 nM	BMPR1A, IC₅₀: 269 nM	ALK4, IC₅₀: 34.6 nM	ALK5, IC₅₀: 4.7 nM	ALK6, IC₅₀: 999 nM	ALK7, IC₅₀: 6.8 nM		ACVR2A, IC₅₀: 671 nM	ACVR2B, IC₅₀: 364 nM
J-1063					ALK5
ALK5-IN-28					ALK5, IC₅₀: ≤10 nM
M4K2306		ALK2, IC₅₀: 7 nM			ALK5, IC₅₀: 3915 nM
ALK2-IN-6		ALK2, IC₅₀: 9 nM
YXX0237												GDF15
DMH-1 (GMP)											BMP
Gdf15 Rat Pre-designed siRNA Set A												GDF15
N-Acetyltaurine hemimagnesium												GDF15

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