TGF-β Receptor Inhibitors

ALK1

ALK2

ALK3

ALK4

ALK5

ALK6

ALK7

TGFβR2

ACVR2A

ACVR2B

BMP

TGF-β Receptor Inhibitors, Agonists, Antagonists & Degraders

Product Name	ALK1	ALK2	ALK3	ALK4	ALK5	ALK6	ALK7	TGFβR2	ACVR2A	ACVR2B	BMP	Purity
SB-431542				ALK4, IC₅₀: 1 μM	ALK5, IC₅₀: 0.75 μM		ALK7, IC₅₀: 2 μM					99.85%
A 83-01				ALK4, IC₅₀: 45 nM	ALK5, IC₅₀: 12 nM		ALK7, IC₅₀: 7.5 nM					99.41%
Dorsomorphin		ACVR1	BMPR1A			ALK6						99.91%
LDN193189		ACVR1, IC₅₀: 5 nM	BMPR1A, IC₅₀: 30 nM									99.72%
THR-123 TFA			BMPR1A									99.91%
Dorsomorphin dihydrochloride		ACVR1	BMPR1A			ALK6						99.91%
RepSox					ALK5, IC₅₀: 4 nM							99.92%
Bimagrumab									ACVR2A, Kd: 434 pM	ACVR2B, Kd: 1.7 pM		99.31%
Vactosertib					ALK5, IC₅₀: 12.9 nM							99.53%
LDN193189 Tetrahydrochloride		ACVR1, IC₅₀: 5 nM	BMPR1A, IC₅₀: 30 nM									99.79%
A 83-01 sodium				ALK4, IC₅₀: 45 nM	ALK5, IC₅₀: 12 nM		ALK7, IC₅₀: 7.5 nM					98.03%
Sotatercept									ACVR2A			99.94%
SB-431542 (GMP)				ALK4, IC₅₀: 1 μM	ALK5, IC₅₀: 0.75 μM		ALK7, IC₅₀: 2 μM
LDN-214117	ALK1, IC₅₀: 27 nM	ACVR1, IC₅₀: 24 nM	BMPR1A, IC₅₀: 1171 nM		ALK5, IC₅₀: 3000 nM							99.54%
GLPG3312									ACVR2A, IC₅₀: 860 nM			98.63%
LDN-212854	ALK1, IC₅₀: 2.4 nM	ACVR1, IC₅₀: 1.3 nM	BMPR1A, IC₅₀: 85.8 nM	ALK4, IC₅₀: 2133 nM	ALK5, IC₅₀: 9276 nM							99.62%
ML347	ALK1, IC₅₀: 46 nM	ACVR1, IC₅₀: 32 nM	BMPR1A, IC₅₀: 10800 nM									99.94%
R-268712					TGFBR1, IC₅₀: 2.5 nM							99.92%
Vactosertib Hydrochloride					ALK5, IC₅₀: 12.9 nM							99.22%
Fidrisertib	ALK1, IC₅₀: 3 nM	ALK2 R206H, IC₅₀: 0.2 nM ALK2, IC₅₀: 0.6 nM		ALK4, IC₅₀: 65 nM	ALK5, IC₅₀: 155 nM	ALK6, IC₅₀: 24 nM		TGF-βR2, IC₅₀: 67 nM	ACVR2A, IC₅₀: 9096 nM			98.17%
THRX-144644					ALK5, IC₅₀: 0.14 nM							99.90%
IN-1130					ALK5							99.93%
Zilurgisertib		ALK2, IC₅₀: 15 nM										98.25%
Ontunisertib					ALK5							99.95%
AZ12601011				ALK4			ALK7					99.78%
EW-7195					ALK5, IC₅₀: 4.83 nM							98.84%
OD36		ACVR1, Kd: 37 nM ACVR1, IC₅₀: 47 nM ALK2 R206H, IC₅₀: 22 nM										99.33%
AZ12799734	ALK1, Kd: 7.1 μM	ACVR1, Kd: 6.2 μM	BMPR1A, Kd: 40 μM	ALK4, Kd: 1 μM	ALK5, Kd: 0.74 μM TGFBR1, IC₅₀: 47 nM	ALK6, Kd: 0.017 μM						98.67%
A 83-01 (Standard)				ALK4, IC₅₀: 45 nM	ALK5, IC₅₀: 12 nM		ALK7, IC₅₀: 7.5 nM
ALK2-IN-2		ACVR1, IC₅₀: 9 nM										99.93%
Itacnosertib		ACVR1, IC₅₀: 8 nM										99.06%
KER047		ALK2										98.80%
Itacnosertib hydrochloride		ACVR1, IC₅₀: 8 nM										99.43%
KER047 succinate		ALK2										98.93%
BI-4659					TGFBR1, IC₅₀: 19 nM							99.78%
M4K-2009		ALK2										99.35%
ALK5-IN-34					ALK5, IC₅₀: <10 nM							98.21%
TGFβRII-IN-3								TGF-βR2, IC₅₀: 4.1 μM				99.51%
CDD-2789	ALK1, Kd: 3.9 nM ALK1, IC₅₀: 10.07 μM	ALK2, Kd: 2.1 nM ACVR1, IC₅₀: 0.54 μM	BMPR1A, Kd: 541 nM		TGFBR1, Kd: 847 nM	ALK6, Kd: 254 nM
OD36 hydrochloride		ACVR1, Kd: 37 nM ACVR1, IC₅₀: 47 nM ALK2 R206H, IC₅₀: 22 nM
M4K2281		ALK2, IC₅₀: 2 nM			ALK5, IC₅₀: 350 nM
THR-123			BMPR1A
ALK5-IN-33					ALK5, IC₅₀: ≤10 nM
J-1149					ALK5, IC₅₀: 0.017 μM
RKER-216		ACVR1, Kd: 58.7 pM
ActRIIB-IN-2										ACVR2B, IC₅₀: 1.1 nM
TGFβRII-IN-2								TGF-βR2, IC₅₀: 2.4 μM
ALK5-IN-85					ALK5, IC₅₀: <100 nM
ALK5-IN-25					ALK5, IC₅₀: ≤10 nM
M4K2308		ALK2, IC₅₀: 2 nM			ALK5, IC₅₀: 224 nM
MU1700	ALK1, IC₅₀: 13 nM	ALK2, IC₅₀: 6 nM				ALK6, IC₅₀: 41 nM
ALK5-IN-27					ALK5, IC₅₀: ≤10 nM
HM-279	ALK1, IC₅₀: 21.0 nM	ALK2, IC₅₀: 64.7 nM	BMPR1A, IC₅₀: 269 nM	ALK4, IC₅₀: 34.6 nM	ALK5, IC₅₀: 4.7 nM	ALK6, IC₅₀: 999 nM	ALK7, IC₅₀: 6.8 nM		ACVR2A, IC₅₀: 671 nM	ACVR2B, IC₅₀: 364 nM
J-1063					ALK5
ALK5-IN-28					ALK5, IC₅₀: ≤10 nM
M4K2306		ALK2, IC₅₀: 7 nM			ALK5, IC₅₀: 3915 nM
ALK2-IN-6		ALK2, IC₅₀: 9 nM
DMH-1 (GMP)											BMP

Name
Email *

	Sorry, but the email address you supplied was invalid.